Article
Characterization of intragenic deletions in two sporadic germinal mutation cases of retinoblastoma resulting in abnormal gene expression.
Oncogene - 1 Mar 1991
Hashimoto T, Takahashi R, Yandell D W, Xu H J, Hu S X, Gunnell S, Benedict W F
Abstract excerpt
Two gross intragenic deletions of the retinoblastoma (RB) gene from patients with sporadic hereditary disease were analysed in detail. This study was undertaken to determine whether there were common mechanisms for these deletions and whether changes found in the tumors were identical to those found in the constitutional cells. Short repeats at the deletion breakpoints were found in both tumors, one resulting in...
Topics
- Base Sequence
- Blotting, Northern
- Blotting, Western
- Chromosome Deletion
- DNA, Neoplasm
- Exons
- Gene Expression Regulation, Neoplastic
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction