Article
Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.
Oncogene - 5 Sept 1996
Ichimura K, Schmidt E E, Goike H M, Collins V P
Abstract excerpt
A series of 195 human gliomas were studied as to the status of their CDKN2A, CDK4 and RB1 genes. Among 120 glioblastomas, 40% had no wild-type CDKN2A gene, 12% amplified the CDK4 gene, and 14% had no wild-type RBI gene. With two exceptions, each tumour had only one of these abnormalities. Thus th...
Topics
- Astrocytoma
- Carrier Proteins
- Chromosome Mapping
- Chromosomes, Human, Pair 13
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- Gene Amplification
- Gene Deletion
- Glioblastoma
- Homozygote
- Humans
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins
- Retinoblastoma Protein