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Article

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.

Oncogene - 5 Sept 1996

Ichimura K, Schmidt E E, Goike H M, Collins V P

Abstract excerpt

A series of 195 human gliomas were studied as to the status of their CDKN2A, CDK4 and RB1 genes. Among 120 glioblastomas, 40% had no wild-type CDKN2A gene, 12% amplified the CDK4 gene, and 14% had no wild-type RBI gene. With two exceptions, each tumour had only one of these abnormalities. Thus the majority of the glioblastomas (64%) had distinct genetic aberrations which would obviously disrupt the control of...

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Source

Identifiers

PMID: 8806696

Genes

CDK4
CCND1
CCND2
CCND3
CDK6
CDK7
MYC
MYCN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.PMID 8806696Read ↗

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.Semantic proximity Read ↗

Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas.Semantic proximity Read ↗

Retinoblastoma gene deletions in human glioblastomas.Semantic proximity Read ↗

Frequent Co‐Alterations of <i>TP53, p16/CDKN2A, p14</i><sup>ARF</sup>, <i>PTEN</i> Tumor Suppressor Genes in Human Glioma Cell Lines.Semantic proximity Read ↗

Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.Semantic proximity Read ↗

Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas.Semantic proximity Read ↗

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastomaSemantic proximity Read ↗

Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.Semantic proximity Read ↗

Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumoursSemantic proximity Read ↗

Alterations of the p53 and pRB pathways in human astrocytoma.Semantic proximity Read ↗

Amplification and Expression of Cyclin D Genes (<i>CCND1 CCND2 and CCND3</i>) in Human Malignant GliomasSemantic proximity Read ↗

Loss of P16INK4 expression is frequent in high grade gliomas.Semantic proximity Read ↗

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