Article
Frequency of IFN beta 1 gene loss in 47 primary human gliomas.
Noshuyo byori = Brain tumor pathology - 1 Jan 1993
Sugawa N, Ekstrand A J, Ueda S, Collins V P
Abstract excerpt
Loss of genetic information from a number of specific regions of the genome has been documented in primary human gliomas. Recently loss of heterozygosity or nullizygosity of the IFN beta 1 gene has been found in glioblastomas. We used Restriction Fragment Length Polymorphism (RFLP) analysis in order to screen the frequency of the loss of this genes in glial tumors of malignancy grades I-IV. Nullizygosity for IFN...
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