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Article

TbMP44 is essential for RNA editing and structural integrity of the editosome in Trypanosoma brucei.

Eukaryotic cell - 1 Jun 2003

Wang Bingbing, Ernst Nancy Lewis, Palazzo Setareh S, Panigrahi Aswini K, Salavati Reza, Stuart Kenneth

Abstract excerpt

RNA editing produces mature mitochondrial mRNAs in trypanosomatids by the insertion and deletion of uridylates. It is catalyzed by a multiprotein complex, the editosome. We identified TbMP44 among the components of enriched editosomes by a combination of mass spectrometry and DNA sequence database analysis. Inactivation of an ectopic TbMP44 allele in cells in which the endogenous alleles were disrupted abolished...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12796303
DOI: 10.1128/EC.2.3.578-587.2003
PMCID: PMC161458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TbMP44 is essential for RNA editing and structural integrity of the editosome in Trypanosoma brucei.PMID 12796303Read ↗

Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei.Semantic proximity Read ↗

RNA editing: complexity and complicationsSemantic proximity Read ↗

The Architecture of Trypanosoma brucei editosomesSemantic proximity Read ↗

Dynamic RNA holo‐editosomes with subcomplex variants: Insights into the control of trypanosome editingSemantic proximity Read ↗

Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex.Semantic proximity Read ↗

TbMP42, a protein component of the RNA editing complex in African trypanosomes, has endo-exoribonuclease activity.Semantic proximity Read ↗

The essential functions of KREPB4 are developmentally distinct and required for endonuclease association with editosomes.Semantic proximity Read ↗

Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization.Semantic proximity Read ↗

RNA editing in trypanosomatid mitochondria.Semantic proximity Read ↗

The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei.Semantic proximity Read ↗

Comparative analysis of editosome proteins in trypanosomatidsSemantic proximity Read ↗

Trypanosome RNA editing: the complexity of getting U in and taking U outSemantic proximity Read ↗

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