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Article

Factor XI deficiency database: an interactive web database of mutations, phenotypes, and structural analysis tools.

Human mutation - 1 Sept 2005

Saunders Rebecca E, O'Connell Niamh M, Lee Christine A, Perry David J, Perkins Stephen J

Abstract excerpt

Factor XI (FXI) is the zymogen of a serine protease enzyme in the intrinsic pathway of blood coagulation and is an important factor in the creation of a stable fibrin clot. Deficiency of FXI leads to an injury-related bleeding disorder and is remarkable for the lack of correlation between bleeding symptoms and FXI coagulant activity (FXI:C). The FXI protein is composed of five domains: four tandem repeat domains...

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PMID: 16086308
DOI: 10.1002/humu.20214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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