Article
Factor XI deficiency--from molecular genetics to clinical management.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jun 2003
O'Connell Niamh M
Abstract excerpt
Factor XI (FXI) deficiency is a rare bleeding disorder, but is known to occur more frequently in a number of well-defined populations. FXI deficiency is most notable for its variable clinical phenotype. The FXI gene is located at the distal end of the long arm of chromosome 4 and encodes a 607 amino acid mature protein, which is a zymogen for a serine protease. Although the serine protease domain is similar to...
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