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Article

Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2005

O'Connell N M, Saunders R E, Lee C A, Perry D J, Perkins S J

Abstract excerpt

BACKGROUND: Factor (F)XI is important in the consolidation phase of blood coagulation. The structural effects of mutations causing FXI deficiency have not been well described due to the lack of a structure for FXI. OBJECTIVES: To develop molecular models of the four apple (Ap) and serine protease (SP) domains in FXI in order to assess the structural effects of published FXI mutations in the light of their...

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Identifiers

PMID: 15634276
DOI: 10.1111/j.1538-7836.2004.01088.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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