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Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency.

Thrombosis and haemostasis - 1 Aug 2009

Saunders Rebecca E, Shiltagh Nuha, Gomez Keith, Mellars Gillian, Cooper Carolyn, Perry David J, Tuddenham Edward G, Perkins Stephen J

Abstract excerpt

Factor XI (FXI) functions in blood coagulation. FXI is composed of four apple (Ap) domains and a serine protease (SP) domain. Deficiency of FXI leads to an injury-related bleeding disorder, which is remarkable for the lack of correlation between bleeding symptoms and FXI coagulant activity (FXI:C). The number of mutations previously reported in our interactive web database (http://www.FactorXI.org) is now...

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PMID: 19652879
DOI: 10.1160/TH09-01-0044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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