Article
Factor XI deficiency.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Nov 2008
Gomez K, Bolton-Maggs P
Abstract excerpt
Although factor XI (FXI) deficiency has a particularly high incidence in Ashkenazi Jews, it is now frequently diagnosed in other ethnic groups. This review gives an overview of the basic pathophysiology, clinical manifestations, and management of FXI deficiency. The correlation between FXI levels and the bleeding phenotype is much less clear than in the haemophilias, and consequently the bleeding risk can be...
Topics
- Adult
- Antifibrinolytic Agents
- Blood Coagulation
- Child
- Coagulants
- Factor XI
- Factor XI Deficiency
- Female
- Founder Effect
- Genetic Testing
- Humans
- Jews
- Male
- Mutation
- Phenotype
- Postoperative Hemorrhage
- Pregnancy