Article
Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.
European journal of medicinal chemistry - 1 May 2010
Kiselyov Alex S, Semenova Marina N, Chernyshova Natalya B, Leitao Andrei, Samet Alexandr V, Kislyi Konstantine A, Raihstat Mikhail M, Oprea Tudor, Lemcke Heiko, Lantow Margaréta, Weiss Dieter G, Ikizalp Nazli N, Kuznetsov Sergei A, Semenov Victor V
Abstract excerpt
A series of novel 1,3,4-oxadiazole derivatives based on structural and electronic overlap with combretastatins have been designed and synthesized. Initially, we tested all new compounds in vivo using the phenotypic sea urchin embryo assay to yield a number of agents with anti-proliferative, anti-mitotic, and microtubule destabilizing activities. The experimental data led to identification of 1,3,4-oxadiazole...
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