Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The clinical development of new mitotic inhibitors that stabilize the microtubule

17 Jun 2004

Abstract excerpt

Microtubule-stabilizing agents are increasingly studied for cancer treatment based largely on the prior success of paclitaxel and docetaxel. In this review, we focus on the clinical development of epothilones and discodermolide, and we discuss salient preclinical and clinical highlights of these two novel natural products. These agents are distinguished by their biochemical features making them poor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 protein interactions
Share to Cancer Treatment and Pharmacology
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15205596
DOI: 10.1097/01.cad.0000131681.21637.b2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The clinical development of new mitotic inhibitors that stabilize the microtubulePMID 15205596Read ↗

Epothilones: Mechanism of Action and Biologic ActivitySemantic proximity Read ↗

The biology and medicinal chemistry of epothilones.Semantic proximity Read ↗

Novel Drugs Targeting Microtubules: the Role of EpothilonesSemantic proximity Read ↗

Epothilone B and its Analogs - A New Family of Anticancer AgentsSemantic proximity Read ↗

Tubulin-Interactive Natural Products as Anticancer AgentsSemantic proximity Read ↗

Microtubule-Stabilizing Natural Products as Promising Cancer TherapeuticsSemantic proximity Read ↗

Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistanceSemantic proximity Read ↗

Targeting Microtubules by Natural Agents for Cancer TherapySemantic proximity Read ↗

Microtubule Targeting Agents as Cancer Chemotherapeutics: An Overview of Molecular Hybrids as Stabilizing and Destabilizing AgentsSemantic proximity Read ↗

Microtubules: A dynamic target in cancer therapySemantic proximity Read ↗

Microtubule Active Agents: Beyond the Taxane FrontierSemantic proximity Read ↗

Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.