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Biological and Teratogenic Evaluations of Nitrogen Heterocycles for Anticancer Therapy

2026-02-04

Abstract excerpt

This study reports the synthesis of four derivatives containing acridine (3a), quinoline (3b), indole (3c), and pyridine (3d) nuclei, as well as their interactions with DNA, physicochemical and pharmacokinetic predictions, antiproliferative activity, in silico and in vivo effects in zebrafish, and enzyme inhibition assays. UV–vis absorption studies with ssDNA revealed different spectroscopic effects, with binding...

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Literature Corpus work
79e8984b-f277-5f07-b05c-04fbbe5d44fd
DOI
10.20944/preprints202602.0328.v1
Open publication

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