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Biological Evaluation and Molecular Modelling Study of Podophyllotoxin Derivatives as Potent Inhibitors of Tubulin Polymerization

21 Jun 2013

Abstract excerpt

Microtubules are considered as important targets of anticancer therapy. Podophyllotoxin and its structural derivative are major microtubule-interfering agents with potent anticancer activity. In this study, we reported the anticancer effects of 10 representative podophyllotoxin derivatives on a panel of four human cancer cell lines. Deoxypodophyllotoxin (6b) and β-apopicropodophyllotoxin (6g) elicited strong...

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PMID: 23786349
DOI: 10.1111/cbdd.12130

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