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Article

Drugs that Inhibit Tubulin Polymerization: The Particular Case of Podophyllotoxin and Analogues

25 Mar 2005

Abstract excerpt

Tubulin being a major cellular target for antitumor drugs, tubulin-interacting compounds have attracted great attention as antimitotic agents. Two main classes of antimitotic drugs are known and one of them includes podophyllotoxin, a natural product. The clinical use of podophyllotoxin in the treatment of cancer has been limited by severe toxic side effects. In an attempt to find less toxic analogues, many...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12678752
DOI: 10.2174/1568011023354353

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