Article
Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines.
Bioorganic & medicinal chemistry - 15 Jan 2014
Demchuk Dmitry V, Samet Alexander V, Chernysheva Natalia B, Ushkarov Vladimir I, Stashina Galina A, Konyushkin Leonid D, Raihstat Mikhail M, Firgang Sergei I, Philchenkov Alex A, Zavelevich Michael P, Kuiava Ludmila M, Chekhun Vasyl F, Blokhin Dmitry Yu, Kiselyov Alex S, Semenova Marina N, Semenov Victor V
Abstract excerpt
A series of 1,5-diaryl- and 4,5-diaryl-1,2,3-triazole derivatives of combretastatin A4 were synthesized and evaluated as antimitotic microtubule destabilizing agents using the sea urchin embryo model. Structure-activity relationship studies identified compounds substituted with 3,4,5-trimethoxyphenyl and 3,4-methylenedioxy-5-methoxyphenyl ring A and 4-methoxyphenyl ring B as potent antiproliferative agents with...
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