Article
Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay.
Bioorganic & medicinal chemistry letters - 15 Aug 2014
Semenova Marina N, Tsyganov Dmitry V, Malyshev Oleg R, Ershov Oleg V, Bardasov Ivan N, Semenov Roman V, Kiselyov Alex S, Semenov Victor V
Abstract excerpt
A series of polyalkoxy substituted 7-hydroxy- and 7-methoxy-4-aryl-4H-chromenes were evaluated using the sea urchin embryo model to yield several compounds exhibiting potent antimitotic microtubule destabilizing activity. Data obtained by the assay were further confirmed in the NCI60 human cancer cell screen. The replacement of methylenedioxy ring A and lactone ring D in podophyllotoxin analogues by 7-methoxy,...
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