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Article

DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants.

Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Mar 2013

Ziyab A H, Karmaus W, Holloway J W, Zhang H, Ewart S, Arshad S H

Abstract excerpt

BACKGROUND: Loss-of-function variants within the filaggrin gene (FLG) are associated with a dysfunctional skin barrier that contributes to the development of eczema. Epigenetic modifications, such as DNA methylation, are genetic regulatory mechanisms that modulate gene expression without changing the DNA sequence. OBJECTIVES: To investigate whether genetic variants and adjacent differential DNA methylation within...

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Source

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Identifiers

PMID: 23003573
DOI: 10.1111/jdv.12000
PMCID: PMC3535679

Genes

FLG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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