Article

Analysis of rare coding variants in 470,000 UK Biobank participants reveals genetic associations with childhood asthma predisposition

2025-02-13

Abstract excerpt

<h4>Background</h4> Previous studies of genetic contributions to risk of childhood asthma have implicated common variants with small effect sizes. Some studies using exome sequence data have reported associations with rare coding variants having larger effects on risk, notably an analysis of 145,000 subjects which found association with loss of function (LOF) variants in FLG , the gene coding for filaggrin. Here w...

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Literature Corpus work: 1a93eb40-eeea-5e9e-b447-a62daf6702a5
DOI: 10.1101/2025.02.12.25322158

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