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Article

Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers.

International journal of cancer - 15 Jul 2008

Danoy Patrick, Michiels Stefan, Dessen Philippe, Pignat Cécile, Boulet Thomas, Monet Marion, Bouchardy Christine, Lathrop Mark, Sarasin Alain, Benhamou Simone

Abstract excerpt

Cigarette smoking is the major risk factor for lung cancer, and together with alcohol for head and neck (H--N) cancer. These genotoxics produced DNA damage and particularly double-strand breaks (DSB) that are removed by various repair pathways. To understand the initiation of these cancers, we performed a genotype analysis to correlate some variants in specific genes in a case-control study of lung and H-N...

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Share to Confounding Factors, Epidemiologic
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Head and Neck Neoplasms

Share to Mutagenesis, Insertional

Share to Rad52 DNA Repair and Recombination Protein

Share to RecQ Helicases

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Source

Identifiers

PMID: 18449888
DOI: 10.1002/ijc.23524

Genes

RAD52
RECQL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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