Article
Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.
Gastroenterology - 1 May 2010
Goel Ajay, Xicola Rosa M, Nguyen Thuy-Phuong, Doyle Brian J, Sohn Vanessa R, Bandipalliam Prathap, Rozek Laura S, Reyes Josep, Cordero Carmen, Balaguer Francesc, Castells Antoni, Jover Rodrigo, Andreu Montserrat, Syngal Sapna, Boland C Richard, Llor Xavier
Abstract excerpt
BACKGROUND & AIMS: Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic pathways and the best diagnostic approaches to detect microsatellite stable (MSS) HNPCC tumors are...
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