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Article

Strategy in clinical practice for classification of unselected colorectal tumours based on mismatch repair deficiency.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Jun 2008

Jensen L H, Lindebjerg J, Byriel L, Kolvraa S, Crüger D G

Abstract excerpt

OBJECTIVE: Deficiency of DNA mismatch repair (MMR) causes microsatellite instability (MSI) in a subset of colorectal cancers. Patients with these tumours have a better prognosis and may have an altered response to chemotherapy. Some of the tumours are caused by hereditary mutations (hereditary nonpolyposis colon cancer or Lynch syndrome), but most are epigenetic changes of sporadic origin. The aim of this study...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
DNA Methylation
DNA Mismatch Repair
DNA-Binding Proteins
Female
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microsatellite Instability

Middle Aged

MutS Homolog 2 Protein

MutS Homolog 3 Protein

Mutation

Source

Identifiers

PMID: 17868408
DOI: 10.1111/j.1463-1318.2007.01378.x

Genes

MLH1
BRAF
MSH2
MSH6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Strategy in clinical practice for classification of unselected colorectal tumours based on mismatch repair deficiency.PMID 17868408Read ↗

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