Article
Changes in cognitive functions of patients with dementia of the Alzheimer type following long-term administration of donepezil hydrochloride: relating to changes attributable to differences in apolipoprotein E phenotype.
Geriatrics & gerontology international - 1 Jan 2010
Kanaya Kiyoshi, Abe Shine, Sakai Minoru, Fujii Hiroko, Iwamoto Toshihiko
Abstract excerpt
AIM: We conducted a study of changes in cognitive functions by long-term monitoring of dementia of Alzheimer type (DAT) patients to investigate the relationship between the progression of DAT symptoms and the presence of apolipoprotein (ApoE)4. METHODS: The subjects consisted of 40 DAT patients who had been treated with donepezil for 3 years or more. The Mini-Mental State Examination (MMSE) and Alzheimer's...
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