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Article

Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?

The American journal of psychiatry - 1 Apr 2005

Hashimoto Mamoru, Kazui Hiroaki, Matsumoto Keiji, Nakano Yoko, Yasuda Minoru, Mori Etsuro

Abstract excerpt

OBJECTIVE: The only approved pharmacological approach for the symptomatic treatment of Alzheimer's disease in Japan is the use of a cholinesterase inhibitor, donepezil hydrochloride. Recent in vivo and in vitro studies raise the possibility that cholinesterase inhibitors can slow the progression of Alzheimer's disease. The purpose of the present study was to determine whether donepezil has a neuroprotective...

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Source

Identifiers

PMID: 15800138
DOI: 10.1176/appi.ajp.162.4.676

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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