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Article

A Longitudinal Item Response Theory Model to Characterize Cognition Over Time in Elderly Subjects.

CPT: pharmacometrics & systems pharmacology - 1 Sept 2017

Vandemeulebroecke Marc, Bornkamp Björn, Krahnke Tillmann, Mielke Johanna, Monsch Andreas, Quarg Peter

Abstract excerpt

For drug development in neurodegenerative diseases such as Alzheimer's disease, it is important to understand which cognitive domains carry the most information on the earliest signs of cognitive decline, and which subject characteristics are associated with a faster decline. A longitudinal Item Response Theory (IRT) model was developed for the Basel Study on the Elderly, in which the Consortium to Establish a...

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PMID: 28643388
DOI: 10.1002/psp4.12219
PMCID: PMC5613212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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