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Effects of APOEɛ4 genotype on age-associated change in cognitive functions among Japanese middle-aged and older adults: A 20-year follow-up study.

Experimental gerontology - 1 Jan 2023

Nishita Yukiko, Sala Giovanni, Shinohara Mitsuru, Tange Chikako, Ando Fujiko, Shimokata Hiroshi, Sato Naoyuki, Otsuka Rei

Abstract excerpt

BACKGROUND AND AIMS: Carriers of the apolipoprotein E ε4 allele (APOEɛ4) have an increased risk of developing dementia (e.g., Alzheimer's disease). However, it is less clear whether the APOEɛ4 might also be involved in cognitive aging among the non-clinical population of older adults. While some studies have suggested that the APOEɛ4 is related to accelerated cognitive decline in the normal aging process, others...

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PMID: 36435340
DOI: 10.1016/j.exger.2022.112036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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