Article
Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype.
Current Alzheimer research - 1 Jan 2014
Albert Marilyn, Soldan Anja, Gottesman Rebecca, McKhann Guy, Sacktor Ned, Farrington Leonie, Grega Maura, Turner Raymond, Lu Yi, Li Shanshan, Wang Mei-Cheng, Selnes Ola
Abstract excerpt
BACKGROUND: This study had two goals (1) to evaluate changes in neuropsychological performance among cognitively normal individuals that might precede the onset of clinical symptoms, and (2) to examine the impact of Apolipoprotein E (ApoE) genotype on these changes. METHODS: Longitudinal neuropsychological, clinical assessments and consensus diagnoses were completed prospectively in 268 cognitively normal...
Topics
- Aged
- Alzheimer Disease
- Apolipoproteins E
- Cognitive Dysfunction
- Disease Progression
- Female
- Genotype
- Humans
- Longitudinal Studies
- Male
- Middle Aged