Article
Clinicopathologic and molecular characteristics of synchronous colorectal cancers: heterogeneity of clinical outcome depending on microsatellite instability status of individual tumors.
Diseases of the colon and rectum - 1 Feb 2012
Bae Jeong M, Cho Nam-Yun, Kim Tae-You, Kang Gyeong H
Abstract excerpt
BACKGROUND: The contribution of chromosomal instability, microsatellite instability, and epigenetic instability to the development of synchronous colorectal carcinomas is controversial. OBJECTIVE: This study aimed to investigate the relative roles of microsatellite instability and epigenetic inst...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- DNA Mismatch Repair
- Epigenesis, Genetic
- Female
- Humans
- Male
- Microsatellite Instability
- Middle Aged
- Mutation
- Neoplasms, Multiple Primary
- Prognosis
- Proto-Oncogene Proteins