Article
Microsatellite instability in multiple colorectal tumors.
International journal of cancer - 31 Mar 1999
Pedroni M, Tamassia M G, Percesepe A, Roncucci L, Benatti P, Lanza G, Gafà R, Di Gregorio C, Fante R, Losi L, Gallinari L, Scorcioni F, Vaccina F, Rossi G, Cesinaro A M, Ponz de Leon M
Abstract excerpt
Tumor multiplicity is a hallmark of hereditary cancers: in the colon-rectum multiple tumors represent 5-10% of all colorectal cancer cases. A portion of these cases belongs to hereditary non-polyposis colorectal cancer (HNPCC), a genetic cancer syndrome due to mismatch repair (MMR) gene mutations, phenotypically expressed as microsatellite instability (MSI); the majority of multiple tumors, however, is apparently...
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