Differential transcriptional and posttranslational transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients.

doi:10.1210/me.2014-1065

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Article

Differential transcriptional and posttranslational transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2014

Pradas-Juni M, Nicod N, Fernández-Rebollo E, Gomis R

Abstract excerpt

Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene is strongly associated with an increased risk of diabetes by 30%-40%. Molecular and clinical studies are of great importance for understanding how this unique variation in TCF7L2 influences type 2 diabetes (T2D) onset and progression. At the molecular level,...

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PMID: 25058603
DOI: 10.1210/me.2014-1065
PMCID: PMC5414799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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