Article
Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant?
Journal of biology - 1 Jan 2010
Mehta Monika, Kim Hyun-Soo, Keogh Michael-Christopher
Abstract excerpt
How much functional specialization can one component histone confer on a single nucleosome? The histone variant H2A.Z seems to be an extreme example. Genome-wide distribution maps show non-random (and evolutionarily conserved) patterns, with localized enrichment or depletion giving a tantalizing suggestion of function. Multiple post-translational modifications on the protein indicate further regulation. An...
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