Article
Fragile X Syndrome and Alzheimer's Disease: Another story about APP and beta-amyloid.
Current Alzheimer research - 1 May 2010
Malter J S, Ray B C, Westmark P R, Westmark C J
Abstract excerpt
As the mechanisms underlying neuronal development and degeneration become clarified, a number of common effectors and signaling pathways are becoming apparent. Here we describe the identification of Abeta, long considered a pathologic mediator of Alzheimers Disease and Down Syndrome, as similarly over-expressed in the neurodevelopmental disease, Fragile X Syndrome. We also show that mGluR5 inhibitors, currently...
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