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Article

Altered expression of Alzheimer's disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy.

Cell death & disease - 22 May 2014

Zeidán-Chuliá F, de Oliveira B-H N, Salmina A B, Casanova M F, Gelain D P, Noda M, Verkhratsky A, Moreira J C F

Abstract excerpt

Autism and Alzheimer's disease (AD) are, respectively, neurodevelopmental and degenerative diseases with an increasing epidemiological burden. The AD-associated amyloid-β precursor protein-α has been shown to be elevated in severe autism, leading to the 'anabolic hypothesis' of its etiology. Here we performed a focused microarray analysis of genes belonging to NOTCH and WNT signaling cascades, as well as genes...

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Identifiers

PMID: 24853428
DOI: 10.1038/cddis.2014.227
PMCID: PMC4047885

Genes

APBB1
GRIN1
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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