Article

miR155 triplicated in Down syndrome regulates hippocampal GABAergic neurogenesis in Alzheimer’s disease

2025-09-30

Abstract excerpt

MicroRNA dysregulation is implicated in neurodegenerative disorders, including Alzheimer’s disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown. We found that MIR155HG (miR155 host gene) colocalizes with APP (amyloid-beta precursor protein) in a neuron-specific, topologically-associated domain (TAD) within a regulatory network, in the obligate porti...

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Literature Corpus work: 8687bf5d-19e4-5433-8a56-14ced69f5b55
DOI: 10.1101/2025.09.28.679053

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