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Article

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52-ssDNA complexes.

Nucleic acids research - 1 May 2010

Grimme Jill M, Honda Masayoshi, Wright Rebecca, Okuno Yusuke, Rothenberg Eli, Mazin Alexander V, Ha Taekjip, Spies Maria

Abstract excerpt

Rad52 promotes the annealing of complementary strands of DNA bound by replication protein A (RPA) during discrete repair pathways. Here, we used a fluorescence resonance energy transfer (FRET) between two fluorescent dyes incorporated into DNA substrates to probe the mechanism by which human Rad52 (hRad52) interacts with and mediates annealing of ssDNA-hRPA complexes. Human Rad52 bound ssDNA or ssDNA-hRPA complex...

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Share to Binding, Competitive
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Resonance Energy Transfer

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Share to Rad52 DNA Repair and Recombination Protein

Share to Replication Protein A

Source

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Identifiers

PMID: 20081207
DOI: 10.1093/nar/gkp1249
PMCID: PMC2875008

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