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DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

15 Mar 2001

Abstract excerpt

DNA double-strand breaks (DSBs) in eukaryotic cells can be repaired by non-homologous end-joining or homologous recombination. The complex containing the Mre11, Rad50 and Nbs1 proteins has been implicated in both DSB repair pathways, even though they are mechanistically different. To get a better understanding of the properties of the human Mre11 (hMre11) protein, we investigated some of its biochemical...

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PMID: 11238998
DOI: 10.1093/nar/29.6.1317

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