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Article

Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans.

Development (Cambridge, England) - 1 Feb 2010

Park Donha, Estevez Annette, Riddle Donald L

Abstract excerpt

The C. elegans daf-8 gene encodes an R-Smad that is expressed in a subset of head neurons, the intestine, gonadal distal tip cells and the excretory cell. We found that DAF-8, which inhibits the DAF-3 Co-Smad, is associated with DAF-3 and the DAF-14 Smad in vivo and in vitro. Overexpression of daf-8 conferred a dauer-defective phenotype and suppressed constitutive dauer formation in daf-8 and daf-14 mutants. In...

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Identifiers

PMID: 20081192
DOI: 10.1242/dev.043752
PMCID: PMC2858912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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