Article
Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation.
Developmental biology - 1 Jan 2000
Inoue T, Thomas J H
Abstract excerpt
Caenorhabditis elegans dauer formation is controlled by multiple environmental factors. The chemosensory neuron ASI regulates dauer formation by secretion of DAF-7/TGF-beta, but the molecular targets of the DAF-7 ligand are incompletely defined and the cellular targets are unknown. We genetically characterized and cloned a putative transducer of DAF-7 signaling called daf-14 and found that it encodes a Smad...
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