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Article

Dominant negative mutations of Caenorhabditis elegans daf-7 confer a novel developmental phenotype.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2013

Crook Matt, Grant Warwick N

Abstract excerpt

BACKGROUND: TGF-β signaling pathways are involved in the control of development in every member of the animal kingdom. As such, TGF-β ligands are widely divergent yet retain a set of core conserved features, specifically, a pre-protein cleavage site and several conserved ligand domain residues, the disruption of which produces a dominant negative phenotype. RESULTS: We have extended these observations into an...

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PMID: 23526825
DOI: 10.1002/dvdy.23963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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