Article
DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer development.
Development (Cambridge, England) - 1 Jan 2004
da Graca Li S, Zimmerman Karen K, Mitchell Melissa C, Kozhan-Gorodetska Marianne, Sekiewicz Kamila, Morales Yairani, Patterson Garth I
Abstract excerpt
An unconventional TGF beta superfamily pathway plays a crucial role in the decision between dauer diapause and reproductive growth. We have studied the daf-5 gene, which, along with the daf-3 Smad gene, is antagonized by upstream receptors and receptor-regulated Smads. We show that DAF-5 is a novel member of the Sno/Ski superfamily that binds to DAF-3 Smad, suggesting that DAF-5, like Sno/Ski, is a regulator of...
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