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Article

Scavenger receptor AI/II truncation, lung function and COPD: a large population-based study.

Journal of internal medicine - 1 Mar 2011

Thomsen M, Nordestgaard B G, Tybjaerg-Hansen A, Dahl M

Abstract excerpt

OBJECTIVES: The scavenger receptor A-I/II (SRA-I/II) on alveolar macrophages is involved in recognition and clearance of modified lipids and inhaled particulates. A rare variant of the SRA-I/II gene, Arg293X, truncates the distal collagen-like domain, which is essential for ligand recognition. We tested whether the Arg293X variant is associated with reduced lung function and risk of chronic obstructive pulmonary...

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Identifiers

PMID: 21077973
DOI: 10.1111/j.1365-2796.2010.02308.x

Genes

FEV

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