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Article

Scavenger Receptor A1 Prevents Metastasis of Non-Small Cell Lung Cancer via Suppression of Macrophage Serum Amyloid A1.

Cancer research - 1 Apr 2017

Zhang Yan, Wei Yongyue, Jiang Bin, Chen Lili, Bai Hui, Zhu Xudong, Li Xiaoyu, Zhang Hanwen, Yang Qing, Ma Junqing, Xu Yong, Ben Jingjing, Christiani David C, Chen Qi

Abstract excerpt

Mechanisms of cross-talk between tumor cells and tumor-associated macrophages (TAM), which drive metastasis, are not fully understood. Scavenger receptor A1 (SR-A1) expressed primarily in macrophages has been associated with lung tumorigenesis. In this study, we used population genetics, transcriptomics, and functional analyses to uncover how SR-A1 is involved in lung cancer and its prognosis. SR-A1 genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28202524
DOI: 10.1158/0008-5472.CAN-16-1569

Genes

SAA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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