Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.

Genes & development - 15 Nov 2006

Sansam Christopher L, Shepard Jennifer L, Lai Kevin, Ianari Alessandra, Danielian Paul S, Amsterdam Adam, Hopkins Nancy, Lees Jacqueline A

Abstract excerpt

Checkpoint genes maintain genomic stability by arresting cells after DNA damage. Many of these genes also control cell cycle events in unperturbed cells. By conducting a screen for checkpoint genes in zebrafish, we found that dtl/cdt2 is an essential component of the early, radiation-induced G2/M checkpoint. We subsequently found that dtl/cdt2 is required for normal cell cycle control, primarily to prevent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cullin Proteins
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G2 Phase

Share to HCT116 Cells

Share to Mitosis

Share to Radiation, Ionizing

Share to Ubiquitin-Protein Ligases

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17085480
DOI: 10.1101/gad.1482106
PMCID: PMC1635147

Genes

CDT1
DTL
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.PMID 17085480Read ↗

Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Semantic proximity Read ↗

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.Semantic proximity Read ↗

Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor.Semantic proximity Read ↗

CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.Semantic proximity Read ↗

CRL4<sup>Cdt2</sup>Semantic proximity Read ↗

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.Semantic proximity Read ↗

The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.Semantic proximity Read ↗

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.Semantic proximity Read ↗

C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein.Semantic proximity Read ↗

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damageSemantic proximity Read ↗

Distinct and sequential re-replication barriers ensure precise genome duplicationSemantic proximity Read ↗

Analyzing the G2/M checkpoint.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.