Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2010

Menendez Daniel, Inga Alberto, Resnick Michael A

Abstract excerpt

p53 is a master regulatory, sequence-specific transcription factor that directly controls expression of over 100 genes in response to various stress signals. Transactivation is generally considered to occur through p53 binding to a consensus response element (RE) composed of two 5'-RRRCWWGYYY-3' decamers. Recently, studying the human angiogenesis-related gene FLT1 we discovered that p53 can mediate limited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen Receptor alpha
Share to Estrogen Receptor beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasms

Share to Response Elements

Share to Transcriptional Activation

Share to Tumor Suppressor Protein p53

Share to Vascular Endothelial Growth Factor Receptor-1

Source

Open in PubMed Open full text

Identifiers

PMID: 20080630
DOI: 10.1073/pnas.0909129107
PMCID: PMC2824383

Genes

FLT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.PMID 20080630Read ↗

The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound.Semantic proximity Read ↗

A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1.Semantic proximity Read ↗

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53Semantic proximity Read ↗

The expanding universe of p53 targets.Semantic proximity Read ↗

Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeuticsSemantic proximity Read ↗

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code.Semantic proximity Read ↗

Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.Semantic proximity Read ↗

Divergent Evolution of Human p53 Binding Sites: Cell Cycle Versus ApoptosisSemantic proximity Read ↗

HIF-transcribed p53 chaperones HIF-1αSemantic proximity Read ↗

p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray dataSemantic proximity Read ↗

Regression based predictor for p53 transactivation.Semantic proximity Read ↗

Redefining the p53 response element.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.