Article
A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1.
Molecular and cellular biology - 1 Apr 2007
Menendez Daniel, Inga Alberto, Snipe Joyce, Krysiak Oliver, Schönfelder Gilbert, Resnick Michael A
Abstract excerpt
Interactions between master regulatory pathways provide higher-order controls for cellular regulation. Recently, we reported a C-->T single-nucleotide polymorphism (SNP) in the vascular endothelial growth factor receptor 1 (VEGFR-1/Flt1) promoter that merges human VEGF and p53 pathways. This finding suggested a new layer in environmental controls of a pathway relevant to several diseases. The Flt1-T SNP created...
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