Article
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2010
Song Hai, Mak Kinglun Kingston, Topol Lilia, Yun Kangsun, Hu Jianxin, Garrett Lisa, Chen Yongbin, Park Ogyi, Chang Jia, Simpson R Mark, Wang Cun-Yu, Gao Bin, Jiang Jin, Yang Yingzi
Abstract excerpt
Control of organ size by cell proliferation and survival is a fundamental developmental process, and its deregulation leads to cancer. However, the molecular mechanism underlying organ size control remains elusive in vertebrates. In Drosophila, the Hippo (Hpo) signaling pathway controls organ size by both restricting cell growth and proliferation and promoting cell death. Here we investigated whether mammals also...
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