Article
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010
Lee Kwang-Pyo, Lee Joo-Hyeon, Kim Tae-Shin, Kim Tack-Hoon, Park Hee-Dong, Byun Jin-Seok, Kim Min-Chul, Jeong Won-Il, Calvisi Diego F, Kim Jin-Man, Lim Dae-Sik
Abstract excerpt
Loss of Hippo signaling in Drosophila leads to tissue overgrowth as a result of increased cell proliferation and decreased cell death. YAP (a homolog of Drosophila Yorkie and target of the Hippo pathway) was recently implicated in control of organ size, epithelial tissue development, and tumorigenesis in mammals. However, the role of the mammalian Hippo pathway in such regulation has remained unclear. We now show...
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