Article
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Nature communications - 19 Feb 2015
Wu Hongtan, Wei Luyao, Fan Fuqin, Ji Suyuan, Zhang Shihao, Geng Jing, Hong Lixin, Fan Xin, Chen Qinghua, Tian Jing, Jiang Mingting, Sun Xiufeng, Jin Changnan, Yin Zhen-Yu, Liu Qingxu, Zhang Jinjia, Qin Funiu, Lin Kwang-Huei, Yu Jau-Song, Deng Xianming, Wang Hong-Rui, Zhao Bin, Johnson Randy L, Chen Lanfen, Zhou Dawang
Abstract excerpt
The role of the unfolded protein response (UPR) in tissue homeostasis remains largely unknown. Here we find that loss of Mst1/2, the mammalian Hippo orthologues, or their regulator WW45, leads to a remarkably enlarged endoplasmic reticulum (ER) size-associated UPR. Intriguingly, attenuation of the UPR by tauroursodeoxycholic acid (TUDCA) diminishes Mst1/2 mutant-driven liver overgrowth and tumorigenesis by...
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