Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Drosophila RASSF homolog antagonizes the hippo pathway.

Current biology : CB - 19 Dec 2006

Polesello Cedric, Huelsmann Sven, Brown Nicholas H, Tapon Nicolas

Abstract excerpt

Correct organ size is determined by the balance between cell death and proliferation. Perturbation of this delicate balance leads to cancer formation . Hippo (Hpo), the Drosophila ortholog of MST1 and MST2 (Mammalian Sterile 20-like 1 and 2) is a key regulator of a signaling pathway that controls both cell death and proliferation . This pathway is so far composed of two Band 4.1 proteins, Expanded (Ex) and Merlin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Size
Share to Carrier Proteins
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Intracellular Signaling Peptides and Proteins

Share to Protein Serine-Threonine Kinases

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17174922
DOI: 10.1016/j.cub.2006.10.060
PMCID: PMC1828611

Genes

MST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila RASSF homolog antagonizes the hippo pathway.PMID 17174922Read ↗

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.Semantic proximity Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Semantic proximity Read ↗

Kibra is a regulator of the Salvador/Warts/Hippo signaling network.Semantic proximity Read ↗

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.Semantic proximity Read ↗

The role of the Hippo pathway in human disease and tumorigenesisSemantic proximity Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ SizeSemantic proximity Read ↗

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.Semantic proximity Read ↗

The bantam microRNA is a target of the hippo tumor-suppressor pathway.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

Elucidation of a universal size-control mechanism in Drosophila and mammals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.