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Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

23 Nov 2010

Abstract excerpt

The mechanisms controlling mammalian organ size have long been a source of fascination for biologists. These controls are needed to both ensure the integrity of the body plan and to restrict inappropriate proliferation that could lead to cancer. Regulation of liver size is of particular interest inasmuch as this organ maintains the capacity for regeneration throughout life, and is able to regain precisely its...

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PMID: 21102585
DOI: 10.1038/sj.bjc.6606011

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