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Article

c-kit is required for cardiomyocyte terminal differentiation.

Circulation research - 28 Mar 2008

Li Ming, Naqvi Nawazish, Yahiro Eiji, Liu Ke, Powell Pamela C, Bradley Wayne E, Martin David I K, Graham Robert M, Dell'Italia Louis J, Husain Ahsan

Abstract excerpt

c-kit, the transmembrane tyrosine kinase receptor for stem cell factor, is required for melanocyte and mast cell development, hematopoiesis, and differentiation of spermatogonial stem cells. We show here that in the heart, c-kit is expressed not only by cardiac stem cells but also by cardiomyocytes, commencing immediately after birth and terminating a few days later, coincident with the onset of cardiomyocyte...

Read the complete abstract on PubMed

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Share to Aorta
Share to Heart Ventricles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertrophy, Left Ventricular

Share to Ligation

Share to Myocardial Contraction

Share to Myocytes, Cardiac

Share to Proto-Oncogene Proteins c-kit

Share to Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 18258857
DOI: 10.1161/CIRCRESAHA.107.161737
PMCID: PMC2763373

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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